Number of deaths in England for ages 15 to 29, by sex and year of registration, from 2015-19 (annual average) to 2021 Sex Table 1: 2021 saw a higher number of excess deaths in males compared with females To explore this further, we compared excess deaths in young people in 2021 with earlier years. This analysis therefore does not indicate any increased risk of cardiac-related deaths or deaths owing to any cause following vaccination. There was also no evidence of a change in the risk of cardiac-related death or death from any cause for any of the subgroups analysed (those aged 12 to 17 years, those aged 18 to 24 years, and those aged 25 to 29 years, males, and females) or by dose or vaccine type they received (see dataset). Therefore, the health of people who have recently received a vaccination is generally better than those who have been vaccinated for a longer time. This may reflect the "healthy vaccine effect", where people who are unwell are more likely to delay vaccination until recovered. A decrease in the risk of death for all causes was observed in the first week after vaccination (0.50, 0.33 to 0.74). There was also no evidence of an elevated risk of all cause death in any of the first six weeks in the risk period after vaccination, and no change in the risk of all cause death in the risk period as a whole (relative incidence 0.94, 95% confidence interval 0.79 to 1.10). Therefore, there is no statistically significant difference. ![]() The risk of death in the first six weeks after vaccination was 0.99 times (95% confidence interval 0.67 to 1.46) that of the risk in the baseline period. There was no evidence of a change in the risk of cardiac-related death in any of the first six weeks in the risk period after vaccination or in the risk period as a whole.
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